Moving toward targeting the right phenotype with the right platelet-rich plasma (PRP) formulation for knee osteoarthritis
نویسندگان
چکیده
Intra-articular injections of platelet-rich plasma (PRP) and other novel blood-derived products developed specifically for osteoarthritis (OA) can provide pain relief potential benefits in disease progression. Meta-analyses show the clinical superiority PRP compared with intra-articular injections, but results are modest effect sizes small. knee OA performed indiscriminately, response varies enormously between patients because an array mixed phenotypes. Subgroup analyses scarce; some studies stratify according to radiographic severity found better early OA, without consensus more advanced stages condition. Parallel identification soluble imaging biomarkers is essential personalise leverage therapies. The inflammatory phenotype most interesting from perspective PRPs modulate inflammation by releasing a large pool chemokines cytokines, which interact synovial fibroblasts macrophages; addition, they innate immune response. No have been discovered that implications research interventions. Clinical examination based on their sources structural alterations could help discern who will respond PRP. Synovial bone marrow lesions pain, combined subchondral injection enhance outcomes. Further refining ultrasound phenotypes may aid personalising delivery altered ligamentous structures, medial coronal ligaments or premeniscal pes anserinus showed positive Although evidence supporting these approaches weak, merit further consideration refine protocols target right
منابع مشابه
Intraarticular Injections of Platelet-rich Plasma (PRP)in the Management of Knee Osteoarthritis
The clinical use of PRP therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. Another reason is the strong advertisement of PRP procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific eviden...
متن کاملPlatelet-rich plasma (PRP) for knee disorders
Platelet-rich plasma (PRP) is an autologous blood product with platelet concentrations above baseline values. The process involves the extraction of blood from the patient which is then centrifuged to obtain a concentrated suspension of platelets by plasmapheresis. It then undergoes a two-stage centrifugation process to separate the solid and liquid components of the anticoagulated blood. PRP o...
متن کاملintraarticular injections of platelet-rich plasma (prp)in the management of knee osteoarthritis
the clinical use of prp therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. another reason is the strong advertisement of prp procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific evidence...
متن کاملIntraarticular Injections of Platelet-rich Plasma (PRP) in the Management of Knee Osteoarthritis.
The clinical use of PRP therapy in the practical setting of orthopaedic fields is increasing partly because of the accessibility of devices that are used in outpatient preparation and delivery. Another reason is the strong advertisement of PRP procedures as the ultimate treatment and novel technology for knee problems by a few orthopaedic surgeons based on claims of abundant scientific evidence...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Musculoskeletal Disease
سال: 2021
ISSN: ['1759-7218', '1759-720X']
DOI: https://doi.org/10.1177/1759720x211004336